Yatsenko Research Group
Principal Investigator:
Alexander Yatsenko, MD, PhD
The Yatsenko Research Group utilizes molecular DNA, RNA and novel genomic high-through put approaches to decipher genetic defects underlying male infertility. His intention is to improve genetic diagnosis for infertile men via application of new procedures and scientific findings into clinical practice. Currently, the diagnosis for male infertility is limited to testing of small proportion of patients for chromosome aberrations. Current therapy available for this condition is IVF and ICSI procedures. While there is no single feature that has been shown to accurately predict the success rate for these procedures or future children’s health born via these technologies.
Using cytogenetic, DNA and RNA sequencing, array comparative genomic hybridization (CGH), and next generation sequencing the group examines hundreds of patients of several disease categories with male infertility for various genetic defects that would cause or influence male infertility. All genetic findings are subject for careful examinations via statistical, computational and functional in vitro and/or vivo approaches. Priorities will be given to novel or known molecular mechanisms causing male infertility that can be modified by medication.
Contact Information
Alexander N. Yatsenko, MD, PhD
Magee-Womens Research Institute
204 Craft Avenue, Room #A206
Pittsburgh, PA 15213
Phone: 412-641-6290
Fax: 412-641-8519
Email
Lab Members
Andrew Georgiadis
Research Technician, Basic Science
Email
Michelle Zorrilla
MWRI Research Counselor
Email
Selected Publications
- Hwang K, Yatsenko AN, Nalam RL, Matzuk MM, & Lamb DJ. Mendelian Genetics of Male Infertility, book chapter (2010). Ann. N.Y. Acad. Sci. 1214 E1–E17. PMID: 21382200
- Yatsenko AN, Yatsenko SA, Cheung SW, Lamb DJ, & Matzuk MM (2010). A comprehensive 5-year study of cytogenetic aberrations in 668 infertile men. J Urol, 183(4):1636-42.
- Yatsenko AN, Iwamori N, Iwamori T, & Matzuk MM (2010). The power of mouse genetics to study spermatogenesis. J Androl, 31(1):34-44.
- Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, & Matzuk MM (2006). Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. Hum Mol Genet, 15 (23):3411-19.
- Wiszniewski W, Yatsenko AN, Zaremba CM, Jamrich M, Wensel TG, Lewis RA, & Lupski JR (2005). ABCA4 mutations causing mislocalization are frequently found in patients with severe retinal dystrophies. Hum Mol Genet, 14 (19):2769-78.
- Yatsenko AN, Wiszniewski W, Zaremba CM, Jamrich M, & Lupski JR (2005). Evolution of ABCA4 proteins in vertebrates. J Mol Evol, 60(1):72-80.
- Yatsenko SA, Yatsenko AN, Szigeti K, Craigen WJ, Stankiewicz P, Cheung SW, & Lupski JR (2004). Interstitial deletion of 10p and atrial septal defect in DiGeorge 2 syndrome. Clin Genet, 66: 128-36.
- Yatsenko AN, Shroyer NF, Lewis RA, & Lupski JR (2003). An ABCA4 genomic deletion in patients with Stargardt disease. Hum Mutatation, 21: 636-44.
Publications on PubMed