Jeyabalan Research Group

Principal Investigator: Arun Jeyabalan, MD, MSCR

Preeclampsia is a multi-organ, pregnancy-specific syndrome that is characterized by systemic vascular dysfunction. Although preeclampsia contributes to significant maternal, fetal, and neonatal morbidity and mortality, the precise pathophysiology of impaired vascular function remains incompletely understood. The broad research aim of the lab is to better understand the mechanisms of vascular dysfunction associated with preeclampsia.

Because the arginase pathway may prove to be a target for preventive and therapeutic strategies in preeclampsia, the lab is studying the role of arginase in preeclampsia and the normal cardiovascular adaptations to pregnancy.

Dr. Jeyabalan leads the clinical data core for the Program Project grant, which addresses cellular and molecular mechanisms of preeclampsia as well as behavioral, epidemiological, and clinical components leading to the disorder. While the current aim is to determine how obesity increases preeclampsia risk, the group also addresses other adverse outcomes of pregnancy such as fetal growth restriction and preterm birth. Seven hundred women will be enrolled and followed over the course of pregnancy and postpartum, and a cross-sectional set of women with preeclampsia, intrauterine growth restriction, or uncomplicated pregnancies will also be enrolled in order to study the long-range associations of preeclampsia and intrauterine growth restriction with the later-life health of the mother and her infant.

Lab Members

Stacy McGonigal, BS
Phone: 412-641-5178

Selected Publications

  • Rajakumar A, Powers RW, Hubel CA, Shibata E, von Versen-Höynck F, Plymire D, & Jeyabalan A. Novel soluble Flt-1 isoforms in plasma and cultured placental explants from normotensive pregnant and preeclamptic women. Placenta, 30:25-31, 2009.
  • Jeyabalan A, McGonigal S, Gilmour C, Hubel CA, & Rajakumar A. Circulating and placental endoglin concentrations in pregnancies complicated by intrauterine growth restriction and preeclampsia. Placenta, 29(6):555-63, 2008.
  • Jeyabalan A, Powers RW, Durica AR, Harger G, Roberts JM, & Ness RB. Cigarette smoke exposure and angiogenic factor in pregnancy and preeclampsia. Am J Hypertens, 21(8):943-47, 2008.
  • Jeyabalan A, Kerchner LJ, Fisher MC, McGuane JT, Doty KD, & Conrad KP. Matrix metalloproteinase-2 activity, protein, mRNA and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats. J Appl Physiol, 100(6):1955-63, 2006.

Publications on PubMed

View Publications on PubMed