Huang Research Group
Principal Investigator:
Xin Huang, PhD
One of the major interests of the Huang lab is the pursuit of biomarkers that can diagnose ovarian cancer early and predict outcomes of ovarian cancer patients. The lab also studies the function of a hypoxia-inducible microRNA, miR-210, in ovarian cancer, because miR-210 is lost in high frequency among ovarian cancer patients, suggesting that miR-210 may be a tumor suppressor.
Lab Members
Langzhu Tan, MD, PhD
Shuping Zhao, MD, PHD
Selected Publications
- Ho AS*, Huang X*, Cao H, Christman-Skieller C, Le QT, & Koong AC. Circulating miR-210 as a novel hypoxia marker in pancreatic cancer. Accepted at Translational Oncology (* equal contributors) (Featured Cover Article)
- Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, & Giaccia AJ. Hypoxia inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Molec Cell, 35(6): 856-67, 2009. (Comments at Molecular Cell, 35:737, 2009; & Nat Rev Cancer 9:769, 2009.)
- Bennewith KL, Huang X*, Ham CM*, Graves EE, Erler J, Kambham N, Feazell J, Yang GP, Koong A, & Giaccia AJ. The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth. Cancer Research 69(3):775-84, 2009. (* equal contributors)
- Huang X, Godfrey TE, Gooding WE, McCarty KS Jr, & Gollin SM. Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma. Genes Chromosomes Cancer, 45(11):1058-69, 2006.
- Hsu LC, Huang X, Seasholtz S, Potter DM, & Gollin SM. Gene amplification and overexpression of protein phosphatase 1alpha in oral squamous cell carcinoma cell lines. Oncogene, 25(40):5517-26, 2006.
- Wu G, Xing M, Mambo E, Huang X, Liu J, Guo Z, Chatterjee A, Goldenberg D, Gollin SM, Sukumar S, Trink B, & Sidransky D. Somatic mutation and gain of copy number of PIK3CA in human breast cancer. Breast Cancer Research, 7(5): R609-16, 2005.
- Huang X, Gollin SM, Raja S, & Godfrey TE. High resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. Proc Nat Acad Sci USA, 99(17):11369-74, 2002.
- Saunders WS, Shuster M, Huang X, Gharaibeh B, Enyenihi AH, Petersen I, & Gollin SM. Chromosomal instability and cytoskeletal defects in oral cancer cells. Proc Nat Acad Sci USA, 97(1): 303-08, 2000.
Links
Visit Dr. Huang’s personal web site