Edwards Research Group

Principal Investigator: Robert Edwards, MD

Dr. Edwards' research interests include cervical and ovarian malignancies. He serves as principle investigator of the Gynecologic Oncology Group for the University of Pittsburgh and for a number of pharmaceutical-sponsored studies. He also serves on the Ovarian Cancer Committee, which experiments with novel therapeutic approaches to gynecologic malignancies and produces translational research.

Three specific targets of Dr. Edwards’ research include:

  • Vaccine therapies for cervical and ovarian cancer

  • Combining biologic and immunologic therapies with traditional therapies in the treatment of women’s cancer

  • Intraperitoneal therapy

Lab Alumni

Jessica Craig, BS

University of South Florida, Tampa FL
PhD candidate in cancer biology, Moffett Cancer Center, Tampa, FL

Kathryn McCabe

Case Western Reserve University, Cleveland, OH
Expected graduation: BS degree 2012

Emily Ott

Drexel University, Philadelphia, PA. Pre-med/chemistry
Expected graduation: BS degree 2013

Hannah Golden

Penn State, State College, PA Microbiology major
Expected graduation 2010

Selected Publications

  • Helm CW, Toler CR, Martin RS III, Gordinier ME, Parker LP, Metzinger DS, & Edwards RP.  Cytoreduction and intraperitoneal heated chemotherapy for the treatment of endometrial carcinoma recurrent within the peritoneal cavity. Int J Gynecol Cancer, 17(1):204-9, Jan.-Feb., 2007.
  • Lenzi R, Edwards R, June C, Seiden MV, Rosenblum M, & Freedman RS. Phase II study of intraperitoneal recombinant interleukin-12 (rhIL012) in patients with peritoneal carcinomatosis (residual disease <1cm) associated with ovarian cancer or primary peritoneal carcinoma. J Translat Med, 5:66, 2007.
  • Fader AN, Edwards RP, Cost M, Kanbour-ShakirA, Kelley JL, Schwartz B, Sukumvanich P, Comerci J, Sumkin J, Elishaev E, & Rohan L. Sentinel lymph node biopsy in early-stage cervical cancer: Utility of intraoperatvie versus postoperative assessment, 2008.
  • Ragin C, Edwards R, Heron D, Kuo J, Wentzel E, Gollin S, & Taioli E. Prevalence of cancer-associated viral infections in healthy Afro-Caribbean populations: A review of the literature. Cancer Investig, 26:936-47, 2008.
  • Lenzi R, Edwards R, June C, Seiden M, Garcia M, Rosenblum M, & Freedman R. Phase II study of intraperitoneal recombinant Interleukin-12 (rhIL-12) in patients with peritoneal carcinomatosis (residual disease <1cm) associated with ovarian cancer or primary peritoneal carcinoma. J Translat Med, 5:66, 2007.
  • Vlad AM, Kettel JD, Edwards RP, & Finn OJ. Mucin 1 (MUC1) glycoprotein modulates the ability of activated T cells to adhere to endothelia through increased binding to ICAM-1 and decreased adhesion to E-Selectin. Submitted, Under Review, J Cell Molec Med, 2009.
  • Finn OJ & Edwards RP. Human papillomavirus vaccine for cane prevention. New Eng J Med, 361:19, Nov. 5, 2009.
  • Naumann RW, Edwards RP, & Sukumvanich P. Practice patterns of intraperitoneal chemotherapy in women with ovarian cancer. Gynecol Oncol, 112:439, May 2009. 
  • Einstein MH, Baron M, Levin MJ, Chatterjee A, Edwards RP, Zepp F, Carletti I, Dessy FJ, Trofa AF, Schuind A, Dubin G, & on behalf of the HPV-010 Study Group. Comparison of the immunogenicity and safety of CervarixTM and GardasilR human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18-45 years. Hum Vacc, 5:10, Oct. 2009.

Publications on PubMed

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