Condon-Jeyasuria Research Group
Principal Investigator:
Jennifer Condon-Jeyasuria, PhD
Researchers at the Condon-Jeyasuria lab focus primarily on defining the mechanisms by which uterine quiescence is maintained throughout pregnancy and lost at term. The lab made the novel observation that non-apoptotic uterine caspase-3 action may inhibit uterine contractility during pregnancy, and has defined uterine caspase-3 as the first uterine gene to be directly regulated by progesterone via direct uterine progesterone receptor interaction.
Lab Members
Evan Easton, MS
Arvind Suresh
Graduate Student
Alyssa Famy-Andersson, MD
Maternal-Fetal Medicine Fellow
Lab Alumni
Kalpana Sudedi, PhD
NIH Bethesda Maryland
R Clifton Moore, MD
Ochsner Medical Center, New Orleans, Louisiana.
Selected Publications
- Jeyasuria P, Wetzel J, Bradley M, Subedi K, & Condon JC. Progesterone-regulated caspase 3 action in the mouse may play a role in uterine quiescence during pregnancy through fragmentation of uterine myocyte contractile proteins. Biol Reprod, 80(5):928-34, 2009.
- Condon J, Hardy DB, Kovaric K, & Mendelson CR. Up-regulation of the progesterone receptor (PR)- C isoform in laboring myometrium by activation of nuclear factor-kappa B may contribute to the onset of labor through inhibition of PR function. Mol Endocrinol, 20(4):764-75, Apr. 2006.
- Mendelson CR & Condon JC. New insights into the molecular endocrinology of parturition. J Steroid Biochem and Molec Biol, 93(2-5):113-9, 2005.
- Condon J, Jeyasuria P, Faust JM, & Mendelson CR. Surfactant protein expression by the fetal lung signals the initiation of labor. Proc Natl Acad Sci USA, (14):4978-83, 2004.
- Condon J, Jeyasuria P, Faust JM, Wilson JW, & Mendelson CR. A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. Proc Natl Acad Sci USA, (100):9518-23, 2003.